Adenovirus vector qdhb

qdhbiReduced Expression in Immortalized Cellsjis the tumor suppressor gene identified and isolated at Okayama University and its function and possible contribution in cancer treatment are getting a good attention.

Carcinogenesis of the cells comes from the abnormality of multiple genes including tumor promoter and tumor suppressor genes. REIC is discovered by Honorary Professor Masayoshi Namba of Okayama University, currently served as president of Niimi public junior college, who named REIC because he found the gene with Reduced Expression in Immortalized Cells. The amino-acid sequence of REIC protein has homogeny with Dkk-3 of Dickkopfs family who plays a crucial role in forming cephalon during embryonic period of a horned frog. Professor Namba discovered REIC has something to do with carcinogenesis signaling pathway and can suppress cancer propagation.

In 2005, a research group in Okayama University discovered that its forced expression using adenoviral vector (Ad-REIC) induces cancer selective apoptosis (cell death) without causing damage to the normal cells in prostate cancer experiment. The abnormality of REIC is observed almost 100% in prostate cancer, approximately 90% in malignant mesothelioma, and also high rate in many other cancers including liver cancer. These evidence shows REIC can apply to many kinds of cancer as a cancer therapeutic gene.
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The following intensive researches have revealed more promising features of REIC as a cancer therapeutic gene. The expression of REIC is significantly reduced in a wide variety of cancer cells and its forced expression using adenoviral vector (Ad-REIC) induces cancer selective apoptosis through the activation of JNK-c-jun pathway due to endoplasmic reticulum (ER) stress (Cancer Res. 2008; 68:8333). Studies using recombinant REIC protein revealed its immunological role in monocyte differentiation into a dendritic-cell phenotype and in vivo tumor regression (Int J Oncol. 2009; 34:657). In addition, its overexpression in normal fibroblasts suppresses tumor growth via induction of interleukin-7, providing an indirect host-mediated effect on cancer cells (J Biol chem. 2009; 284: 14236). Local and systemic 'bystander' anti-tumor effects generated by in situ Ad-REIC gene therapy were confirmed in orthotopic animal models using prostate cancer and malignant mesothelioma cells.
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We currently focus our energy on realizing Phase I/II clinical study for prostate cancer and malignant mesothelioma using adenovirus vector REIC in the US and Japan to establish its proof of concept (POC) as a real innovative medicine for cancer, which will lead us to collaborate with pharmaceutical companies.



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Momotaro-Gene Inc. possesses the Master virus Bank for Adeno IL-12 manufactured by Baylor College of Medicine in Texas, US. With this material, we will support International collaborative research planed by Okayama University, Beijing University, Zhejiang University, Korea Catholic University and Singapore General Hospital. Interleukin is one of the cytokines secreted by leukocyte and plays a role of communication among cells. IL-12 has strong cancer immunostimulant capability such as activation of natural killer cells (NK cells) and induing Th1 cells and cytotoxic lymphocytes (CTL).
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Momotaro-Gene Inc.
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